http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003225370-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7733de6f1f3f113100ed2fd12c4a3f68 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-2212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2025-0089 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2090-064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-22082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-22077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-221 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2018-00392 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-00247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2210-125 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-3207 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-22 |
| filingDate | 2003-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0bdfed801136ed1eb59ba3c47d9ceaf |
| publicationDate | 2003-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003225370-A1 |
| titleOfInvention | Apparatus and method for delivering therapeutic and diagnostic agents |
| abstract | The present invention provides an drug-delivery tool and method for delivering a selected diagnostic or therapeutic agent to a target site within a selected body tissue, such as the myocardium of the heart. In one embodiment, the drug-delivery tool is configured to be introduced percutaneously for intravascular delivery into temporary cavities formed in the myocardium from the epicardial surface. In another embodiment, the drug-delivery tool is configured for intraoperative use, to be introduced thoracoscopically or through a thoracotomy, to form temporary cavities in the myocardium from the epicardial surface. The drug-delivery tool generally comprises an accessing device having a tissue-penetrating implement in its distal-end region, and means for delivering a selected agent in a cavity formed by the implement. In an exemplary use, wherein a patient's heart is treated with an agent for transferring genetic information to the heart tissue, the distal end of the accessing device is conditioned adjacent a selected region of the heart wall, and the tissue-penetrating implement is advanced to form a temporary channel in the myocardium. The gene-therapy agent is introduced into the cavity by the delivery means and retained therein by means overcoming the intra-myocardial pressures. In one embodiment, the treated tissue is stunned, ischemic or hibernating organ tissue that has at least partially lost its normal capillary ability at natural vasomotion. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8414765-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012004597-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7713232-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646109-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011028908-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9629780-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8182444-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008294096-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008086111-A1 |
| priorityDate | 1999-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.