| abstract |
A one-pot process for preparing 2,6-diaminopurine derivatives or an acid addition salt thereof comprising: (i) reacting a purine compound with an amine compound in the presence of a tertiary amine at a pH of 7 to 14 to form a 6-substituted aminopurine derivative, and (ii) reacting the 6-substituted aminopurine with an aromatic amine in the presence of an acid catalyst at a pH of 0.1 to less than 7. |