abstract |
The invention provides novel selective estrogen receptor modulator compounds of the general formula: n n n wherein R1 and R2, which are the same or different are n a) H, halogen, OCH 3 , OH; or n n n where X is O, NH or S; and n is an integer from 1 to 4; and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, —CH 2 C≡CH or —CH 2 CH 2 OH; or R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring; or n c) —Y—(CH 2 ) n CH 2 —O—R6 n where Y is O, NH or S and n is an integer from 1 to 4; and R6 is H, —CH 2 CH 2 OH, or —CH 2 CH 2 Cl; or n d) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy; and n R3 is H, halogen, OH or —OCH 3 ; n stereoisomers thereof and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds exhibit valuable pharmacological properties. |