abstract |
The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula n n n wherein n W represents —C(═O)— or —CH(OH)—; n R 1 represents hydrogen or hydroxy; n R 2 represents hydrogen; n R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 ; n n is an integer of from 1 to 5; n m is an integer 0 or 1; n R 3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched n each of A is hydrogen or hydroxy; and n pharmaceutically acceptable salts and individual optical isomers thereof, n with the proviso that where R 1 and R 2 are ta to form a second bond between the carbon R 1 and R 2 or where R 1 represented hydrox integer 0. |