| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-292
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-38 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 |
| filingDate |
2001-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f38b0ebf2fdc5f49b5964ad24eb79ad5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94a7694fb1a6c4a5d2bfe7f698014612 |
| publicationDate |
2003-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003220304-A1 |
| titleOfInvention |
Hydroxyphenstatin and the prodrugs thereof |
| abstract |
The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective anti neoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111333495-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104892668-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017030983-A1 |
| priorityDate |
2000-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |