| abstract |
A topical formulation including a solvent, an occlusive agent, a surfactant system, an androstane steroid compound of formula (I) wherein R 1 represents a fluoro-, chloro- or bromo-methyl group or a 2′-fluoroethyl group, R 2 represents a group COR 6 where R 6 is a C 1-3 alkyl group or OR 2 and R 3 together form a 16α, 17α-isopropylidenedioxy group; R 3 represents a hydrogen atom, a methyl group (which may be in either the α- or β-configuration) or a methylene group; R 4 represents a hydrogen, chlorine or fluorine atom; R 5 represents a hydrogen or fluorine atom and the symbol --- represents a single or double bond, and the balance being water. |