| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f009fff2f31da9529566f0ef0e9f3b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f244c6155c2c1d73694b62b1c889927 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-42 |
| filingDate |
2003-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c626d850ec89bab2e8822a6fe31c6961
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92eed37c4d2a7e8d97c5a9b349f73490
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9aee52a771af7cb9b9d833bd680b7246 |
| publicationDate |
2003-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003215899-A1 |
| titleOfInvention |
Reversible oxidation of protein tyrosine phosphatases |
| abstract |
The invention relates to a method of identifying any protein tyrosine phosphatase (PTP) that undergoes reversible modification of PTP active site invariant cysteine within a cell, such that the phosphatase is transiently protected from irreversible active site invariant cysteine-directed PTP inactivating agents. Methods related to regulation of PTPs by reactive oxygen species (ROS) in a cellular environment are provided. Multiple PTPs are shown to be reversibly oxidized and inactivated following treatment of cells with H 2 O 2 or with physiological stimuli that promote ROS formation, and inhibition of PTP function is shown to contribute to ROS-induced mitogenesis. Transient oxidation of the PTP catalytic site invariant cysteine is exploited in methods to identify which of multiple candidate PTPs are components of a given biological signal transduction pathway, without a requirement for first specifically purifying any particular candidate PTP. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010113331-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005187277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136389-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7449555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7723369-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014088113-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004186151-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004192743-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10597452-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013029366-A9
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074002-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10604569-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006002931-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111521817-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8404731-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180551-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011092553-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9279811-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005117970-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10894824-B2 |
| priorityDate |
2002-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |