| abstract |
The invention concerns peptides derived from helimomicine by substitution of one or several amnio acids, characterised in that the peptides correspond to formula (I) : X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , C 7 , X 8 , X 9 , X 10 , X 11 , X 12 , X 13 , X 14 , X 15 , X 16 , X 17 , C 18 , X 19 , X 20 , X 21 , C 22 , X 23 , X 24, X25, X 26 , X 27 , X 28 , X 29 , X 30 , X 31 , X 32 , X 33 , X 34 , X 35 , X 36 , X 37 , X 38 , X 39 , C 40 , X 41 , C 42 , X 43 , X 44 wherein X 1 , X 17 , X 21 , X 43 are amino acids; X 16 , X 44 are small polar amino acids; X 19 is a large polar amino acid; X 36 is a small or lightly hydophobic amino acid; X 38 is a lightly hydrophobic or small amino acid; the substitutions being such that: at least one of X 1 , X 17 , X 21 , X 43 is a basic or polar, advantageously large polar amino acid, and/or at least one of the amnio acids X 16 , X 44 is a basic amino acid or a large polar amino acid, and/or X 19 is a basic amino acid, and/or at least one of the amino acids X 36 , X 38 is a strongly hydrophobic amino acid. The invention also concerns antifungal and/or antibacterial compositions comprising at least one of the peptides. |