| abstract |
A compound of formula 1 n n n wherein: n X − is an anion with a single negative charge; n A and B, which are identical or different, are each —O—, —S—, —NH—, —CH 2 —, —CH═CH—, or —N(C 1 -C 4 -alkyl)-; n R is hydrogen, hydroxy, —C 1 -C 4 -alkyl, —C 1 -C 4 -alkyloxy, —C 1 -C 4 -alkylene-halogen, —O—C 1 -C 4 -alkylene-halogen, —C 1 -C 4 -alkylene-OH, —CF 3 , —CHF 2 , —C 1 -C 4 -alkylene-C 1 -C 4 -alkyloxy, —O—COC 1 -C 4 -alkyl, —O—COC 1 -C 4 -alkylene-halogen, —C 1 -C 4 -alkylene-C 3 -C 6 -cycloalkyl, —O—COCF 3 , or halogen; n R 1 and R 2 , which are identical or different, are each —C 1 -C 5 -alkyl, which is optionally substituted by —C 3 -C 6 -cycloalkyl, hydroxy, or halogen, or n R 1 and R 2 together are a —C 3 -C 5 -alkylene bridge; n R 3 , R 4 , R 3′ , and R 4′ , which are identical or different, are each hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkyloxy, hydroxy, —CF 3 , —CHF 2 , —CN, —NO 2 , or halogen; n R x and R x′ , which are identical or different, are each hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkyloxy, hydroxy, —CF 3 , —CHF 2 , —CN, —NO 2 , or halogen, or n R x and R x′ together are a single bond or a bridging group selected from —O—, —S—, —NH—, —CH 2 —, —CH 2 —CH 2 —, —N(C 1 -C 4 -alkyl)-, —CH(C 1 -C 4 -alkyl)-, and —C(C 1 -C 4 -alkyl) 2 -, n or a pharmacologically acceptable acid addition salt thereof, processes for preparing, them and their use in pharmaceutical compositions. |