Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2278 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 |
filingDate |
2000-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d81a97bba705a62055a10feed74a19cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0aee62a8743ea1269bdd64b3abcb164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_087ddbd0ce25bf1632c26cdf7d86c14e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_693ee6f21e872c18b0e6a265cbe1e2a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b693965ccec87150238d94c8d12621e |
publicationDate |
2003-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2003207802-A1 |
titleOfInvention |
Polypeptide compositions with improved stability |
abstract |
The present invention provides means to improve the chemical stability of aqueous, parenteral pharmaceutical compositions comprising a polypeptide and glycerin. Reactive aldehydes are identified in commercial glycerins, and means for reducing such are provided. Convenient means are provided to assay for reactive aldehydes in glycerin, and a strong linear correlation between the level of reactive aldehydes in glycerin and chemical stability of compositions comprising a polypeptide and glycerin is demonstrated. The invention includes aqueous compositions comprising a polypeptide and glycerin having improved chemical stability compared to compositions previously known. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007010424-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9097692-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11752198-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012083039-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010056451-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11318191-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8114833-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8748376-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710181-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008171848-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8614181-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010234299-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846618-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2191847-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010057624-A1 |
priorityDate |
1999-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |