| abstract |
A metered dose inhaler having part or all of its internal surfaces coated two or more times with a polymer comprising one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, containing an inhalation drug or a physiologically acceptable salt thereof, optionally an excipient and a fluorocarbon propellant. Also, a method for coating all or part of internal surfaces of a metered dose inhaler can comprising applying a first coat comprising a one or more fluorocarbon polymers to all or part of the internal the surfaces of a metered dose inhaler can. Subsequently, heating the first coat of fluorocarbon polymer and then applying a second coat comprising one or more fluorocarbon polymer on top of the first coat of fluorocarbon polymer. The two coats of fluorocarbon polymer are then heated to give a metered dose inhaler can that is more efficient in dispensing consistent doses of aerosol formulations. |