| abstract |
Compounds of a histone deacetylase inhibitor. The compounds are capable of simultaneously modulating cell cycle-related gene expression and inflammatory cytokine production, and are useful as anti-inflammatory agents in connective tissue disease resulting from altered patterns of immunoregulation. The present invention provides methods of treating, preventing or ameliorating connective tissue diseases, which share common features including inflammation of skin, joints and soft tissues as well as altered patterns of immunoregulation, by administering a therapeutically effective amount of a histone deacetylase inhibitor. |