abstract |
The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH 3 —(CH 2 ) n —CH 2 OH or saturated fatty acid CH 3 —(CH 2 ) n —CH 2 COOH wherein n is an integer number 8÷22, preferably 8÷12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH 3 (C n H 2(n−1) )—OH or CH 3 (C n H 2(n−1) )—COOH wherein n is an integer number 8÷22, b) a ternary vehicle or carrier consisting of a C 1 ÷C 4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol. |