| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6901
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-16001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-864 |
| filingDate |
2002-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b42394c3d9a7d73d058179a790b0d177
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1b4b3b62726ac1c72f80be05f5ccdbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed50f857f3303d76f0b34d79a3200258 |
| publicationDate |
2003-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003198620-A1 |
| titleOfInvention |
Method of treating amino acid metabolic disorders using recombinant adeno-associated virus virions |
| abstract |
Methods for delivering a heterologous gene to a mammalian subject using recombinant adeno-associated virus (rAAV) virions are described. Recombinant AAV virions containing a heterologous gene encoding a metabolic protein are delivered to a mammalian subject having a metabolic disorder. The rAAV virion-delivered heterologous gene is expressed at a therapeutic level thereby ameliorating a sign or symptom of the metabolic disease. Exemplary examples of metabolic diseases are those caused by defects in aromatic amino acid metabolism. Exemplary examples of heterologous genes include those encoding an aromatic amino acid hydroxylase, aromatic amino acid decarboxylase, and enzymes involved in tetrahydrobiopterin synthesis. Methods for treating phenylketonuria are also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102528641-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111433368-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004142416-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9572870-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3746113-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10597685-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3746101-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3003358-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200127187-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019036484-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110325199-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11077238-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014134689-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11040088-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010009997-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111902164-A |
| priorityDate |
2002-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |