| abstract |
The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. n Accordingly, the present invention provides a production method of bicalutamide represented by the formula (I): n n n which includes at least a step of reacting a compound represented by the formula (3): n n n with an oxidizing agent, a production method of a crystal of bicalutamide, as well as a crystal form of bicalutamide as defined by X-ray diffraction (XRD) or solid 13 C NMR measurement. |