Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd47318319f20f7f99d9fef1fd3e511b |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-83 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C247-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate |
2003-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7434ae35a21000d98d74d8b74e9bf973 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0053fdd605ff50d69b1c3d9a4ca0eba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9b20232a1312640b4134e86d781ede0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f34377c8cbdfc35bf1e2c8f4e10bfe10 |
publicationDate |
2003-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2003191322-A1 |
titleOfInvention |
Synthesis of clasto-lactacystin beta-lactone and analogs thereof |
abstract |
The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteosome inhibitors. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008161282-A1 |
priorityDate |
1997-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |