| abstract |
An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: n n n wherein: n A is O, S, NR 1 , or CR 1 , wherein R 1 is defined herein; n ---- represents either a single or a double bond; n R 2 is selected from: H, halogen, R 21 , OR 21 , SR 21 , COOR 21 , SO 2 N(R 22 ) 2 , N(R 22 ) 2 , CON(R 22 ) 2 , NR 22 C(O)R 22 or NR 22 C(O)NR 22 wherein R 21 and each R 22 is defined herein; n B is NR 3 or CR 3 , with the proviso that one of A or B is either CR 1 or CR 3 , n wherein R 3 is defined herein; n K is N or CR 4 , wherein R 4 is defined herein; n L is N or CR 5 , wherein R 5 has the same definition as R 4 defined above; n M is N or CR 7 , wherein R 7 has the same definition as R 4 defined above; n Y 1 is O or S; n Z is N(R 6a )R 6 or OR 6 , wherein R 6a is H or alkyl or NR 61 R 62 wherein R 61 and R 62 are defined herein; n a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase. |