http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003171371-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-30 |
| filingDate | 2001-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ece62ae8d6f74eb664731532786c0a4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74bc7827f551583c0e5d9d755f0cbf66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8366782f91765010cb631c996da4d535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b59e5c330a3130365e11e11aa180132d |
| publicationDate | 2003-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003171371-A1 |
| titleOfInvention | Immunosuppressant n-acyles homoserine lactones |
| abstract | New N-acyl homoserine lactone compounds of the formula (I) in whichR is an acyl group of the formula (II) wherein one of R 1 and R 2 is H and the other is selected from OR 4 , SR 4 and NHR 4 , wherein R 4 is H or 1-6C alkyl, or R 1 and R 2 together with the carbon atom to which they are joined form a keto group, and R 3 containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, carbamoyl optionally mono- or disubstituted at the N atom by 1-6C alkyl and NR 5 R 6 wherein each of R 5 and R 6 is selected from H and 1-6C alkyl or R 5 and R 6 together with the N atom form a morpholino or piperazino group, or and enantiomer thereof, with the proviso that R is not a 3-oxododecanoyl group, having immuosuppressant properties are disclosed. The compounds are shown to have an inhibitory effect on lymphocyte proliferation and down-regulate TNF-α secretion by monocytes/macrophages in the animal body, including the human body. Pharmaceutical composition comprising N-acyl homoserine lactones are also described. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I594991-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004115245-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10702497-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019111023-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7651699-B2 |
| priorityDate | 2000-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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