| abstract |
Compounds represented by formula I: n n n wherein R 2 is H, halogen, NHNH 2 , (C 1-4 )alkyl, O(C 1-6 )alkyl, and haloalkyl; R 4 is H or Me; R 5 is H or (C 1-4 )alkyl; R 11 is (C 1-4 )alkyl, (C 1-4 )alkyl(C 3-7 )cycloalkyl, or (C 3-7 )cycloalkyl; and Q is naphthyl, fused phenyl(C 4-7 )cycloalkyl and fused phenyl-5, 6, or 7-membered saturated heterocycle having one to two heteroatom selected from O, N, or S, said Q being substituted with from 1 to 4 R 12 substituents selected from: R 13 , (C 1-6 )alkyl, (C 3-7 )cycloalkyl, or (C 2-6 )alkenyl, said alkyl, cycloalkyl, or alkenyl being optionally substituted with R 13 ; or a salt thereof. Compounds represented by formula I have inhibitory activity against Wild Type, single and double mutant strains of HIV. |