| abstract |
The instant invention is a method for increasing a metazoan's lifespan, comprising administering a carboxylated derivative of a C 60 fullerene. The instant invention further is a process for extending a metazoan's lifespan by administering a superoxide dismutase-mimetic as well as a composition comprising a superoxide dismutase-mimetic. Further, the instant invention comprises a pharmaceutical composition comprising carboxyfullerenes having x pairs of adjacent carbon atoms bonded to two carbons of the C 60 sphere wherein said adjacent carbon atom is further bonded to two groups of the general formula —COOH and —R, wherein R is independently selected from the group consisting of —COOH and —H, and wherein x is at least 1. n A further embodiment is a non-metal containing composition which can catalytically eliminate two biologically reactive species. n Another embodiment is a method of enhancing elimination of reactive oxygen species in eukaryotic cells by contacting cells with a superoxide dismutase mimetic. |