| abstract |
The present invention is directed to labeled compounds, [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfones and [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfoxides, wherein the 13 C methyl group attached to the sulfur of the sulfone or sulfoxide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure n n n wherein R 1 , R 2 , R 3 , R 4 and R 5 are each independently, hydrogen, a C 1 -C 4 lower alkyl, a halogen, an amino group from the group consisting of NH 2 , NHR and NRR′ where R and R′ are each a C 1 -C 4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing methyl aryl sulfones and methyl aryl sulfoxides. |