| abstract |
The present invention relates to new deoxyribonucleic acid (DNA) constructs, to vectors and host organisms which contain these DNA constructs and which, owing to their use in specific methods, are suitable for indicating the loss of correct splicing, and to the use of these transgenic organisms or cells for identifying new active substances, and, finally, to methods of finding new active substances which are capable of preventing correct splicing and to the use of these methods in high-throughput screening (HTS) or ultra-high-throughput screening (UHTS). |