http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003147949-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-906 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2036 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate | 2002-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1d1f077889f6f132b948d47c5c2809f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f8c88dd8a02a1ddc6fdcc8d7d22ee5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa0188211f5c500ef59ca73729299a7c |
| publicationDate | 2003-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003147949-A1 |
| titleOfInvention | Pharmaceutical excipient having improved compressibility |
| abstract | A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007243871-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2314296-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004005357-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6858231-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009074862-A1 |
| priorityDate | 1995-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 606.