| abstract |
The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include n n n as part of their structure and bind to a FK binding protein wherein R 4 and R 5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R 4 and R 5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs. |