| abstract |
The present invention provides novel polypeptides having physiological activity related to anterior pituitary hormones (such as LH, FSH, and TSH), DNAs coding for such polypeptides, methods for screening compounds or their salts which promote or inhibit the activity of the polypeptides of the present invention, and the like. n The polypeptides of the present invention have physiological activity related to anterior pituitary hormones (such as LH, FSH, and TSH), and can thus be used as a drug for the treatment of hypertension, autoimmune diseases, cardiac failure, and the like. The polypeptides of the present invention are also useful as a reagent for screening compounds or their salts which promote or inhibit the activity of the polypeptides of the present invention; and said compounds obtained by such screening are promising as a drug for the prevention and treatment of hypertension, autoimmune diseases, cardiac failure, and the like. Antibodies against the polypeptides of the present invention are also capable of specifically recognizing the polypeptides of the present invention, and can thus be used for quantification and the like of the polypeptides of the present invention in samples. |