| abstract |
This invention concerns the compounds of formula (I), n n n the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2, 3, 4, 5 or 6; X is CH 2 or O; R 1 and R 2 each independently are hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, halomethylcarbonyl or C 1-6 alkyl substituted with hydroxy, C 1-6 alkyloxy, carboxyl, C 1-6 alkylcarbonyloxy, C 1-6 alkyloxycarbonyl or aryl; or R 1 and R 2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; R 3 and R 4 are both halogen; or R 3 is halogen and R 4 is hydrogen; or R 3 is hydrogen and R 4 is halogen; and aryl is phenyl or phenyl substituted with 1, 2 or 3 substituents selected from halo, hydroxy, C 1-6 alkyl and halomethyl. The compounds of formula (I) may be used as therapeutic agents. |