| abstract |
The invention provides isolated nucleic acids molecules, designated 18080 nucleic acid molecules, which encode serine carboxypeptidase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18080 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18080 gene has been introduced or disrupted. The invention still further provides isolated 18080 proteins, fusion proteins, antigenic peptides and anti-18080 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. Methods utilizing compositions of the invention to treat, prevent or diagnose hematopoietic disorders, e.g., erythroid-associated disorders, are also provided. |