http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003133910-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2002-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb3db4961ab2056c127de50091de5761 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_111705a0bd0fb1f52b66b988ad9018a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20b917ff6c7a2020067ea4c9bc752f3d |
| publicationDate | 2003-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003133910-A1 |
| titleOfInvention | Wild-type ras as a cancer therapeutic agent |
| abstract | Methods for inhibiting proliferation of a cell, particularly a cancer cell are provided. The method comprises increasing intracellular levels of one or more wild-type ras proteins in the cell. In one aspect, the method comprises introducing and expressing a nucleic molecule that encodes a wild-type ras protein in the cell. In another aspect, intracellular levels of one more ras proteins are increased by introducing one or more wild-type ras proteins into the cell. The present invention also relates to the therapeutic use of wild-type ras proteins or nucleic acids that encode one or more wild-type ras proteins in the treatment of tumors or cancer, or prophylactically to prevent formation of tumors or cancer. Methods of characterizing or evaluating cancer in a humans or other mammals are provided. In one embodiment, the method comprises assaying for a loss of function mutation in one or more endogenous ras alleles in the genome of tumor cells obtained from the subject. In another embodiment, the method comprises assaying for a loss of function mutation in one or more endogenous ras alleles and an activating mutation in one or more ras alleles in tumor cells obtained from the subject. |
| priorityDate | 2001-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 204.