| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2003-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e636b5797635a2d3e3e6cee2bf4c6be2 |
| publicationDate |
2003-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003131364-A1 |
| titleOfInvention |
Method for producing transgenic animal models with modulated phenotype and animals produced therefrom |
| abstract |
A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer's Disease (AD) and the transgenic animal made by the method is disclosed. The method includes producing an F 1 generation by crossing a first and second transgenic parent each carrying a different expressible transgene for differing aspects of the same desired phenotype associated with AD pathology. The offspring of the F 1 generation are then screened and those which carry a transgene from each parental transgenic animal resulting in an enhanced pathology for Alzheimer's Disease are selected. In a preferred embodiment the AD-associated pathology is for amyloid accumulation. In an embodiment a mutant presenilin transgene and a transgene for a mutant amyloid precursor protein are used. In a further embodiment the mutant presenilin transgene is the PS1 M146L mutation and the mutant amyloid precursor protein transgene is the Swedish mutation (APP695 isoform containing a K670N,M671L mutation (APP770 numbering)). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012071592-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008070995-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011165146-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012071592-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10765093-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012103218-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103348012-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7897361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005089539-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103348012-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006035237-A3 |
| priorityDate |
1999-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |