| abstract |
Disclosed is a method of extracting nucleic acids from blood which comprises contacting blood cells, preferably after lysing with an activated solid phase at one pH to immobilize the nucleic acids and then removing the nucleic acids at a higher pH when the charge has been reversed or neutralized. The solid phase can be beads activated by a histidine as a binding agent. The beads can be fluidized by sucking the blood with air up through a column containing the beads to improve contact and prevent clogging. |