| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1812
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1217
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-586 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12 |
| filingDate |
2002-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a582ba661c8a7f00f3788947d6b7fbf1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74c1bb4694ca6c9b5549cbd244ade23e |
| publicationDate |
2003-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003129136-A1 |
| titleOfInvention |
Methods for targeted drug delivery |
| abstract |
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10328182-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012047582-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11246965-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006239919-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10449269-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012047582-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9642926-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014506867-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015168674-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103648484-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107638574-A |
| priorityDate |
1995-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |