http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003125575-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-363 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C321-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-363 |
| filingDate | 2001-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dc2f379f451d1b5c0e0f72d4afbc9a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87cdbf726da1c9ff1f8d8187e46429fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e7b786668306a6e1eaacbac2e8eba2f |
| publicationDate | 2003-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003125575-A1 |
| titleOfInvention | Process for the preparation of(R)-2-bromo-3-phenyl -propionic acid |
| abstract | Process for the preparation of (R)-2-bromo-3-phenylpropionic acid starting from D-phenylalanine, sodium nitrite and HBr in an aqueous solution, the reaction being carried out in the presence of a bromide salt, at a temperature between −10 and 30° C. n The total amount of HBr plus bromide salt lies between 3 and 10 equivalents, calculated relative to the amount of D-phenylalanine, preferably between 4 and 8 equivalents, the amount of bromide salt ranging from 0.5 to 7 equivalents, calculated relative to the amount of D-phenylalanine. The bromide salt is preferably formed in situ from HBr and a base, for instance KOH or NaOH. Preferably, the (R)-2-bromo-3-phenylpropionic acid obtained is subsequently converted into (S)-2-acetylthio-3-phenylpropionic acid using thioacetic acid and an organic base, for instance triethylamine. The (S)-2-acetylthio-3-phenylpropionic acid obtained can be converted into a pharmaceutical, in particular an ACE inhibitor, for instance Omapatrilat. |
| priorityDate | 2000-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.