| abstract |
This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): n n n where R 1 is H, alkyl or phenylalkyl; R 2 is H, alkyl, alkenyl or phenylalkyl; or R 1 and R 2 taken together as Z are —CH 2 C—H 2 —, —CH 2 C(R 6 )(R 7 )CH 2 — or —CH 2 C(R 8 )(R 9 )—C(R 10 )(R 11 )CH 2 —, where R 6 , R 8 and R 10 are, independently, H, alkyl or hydroxyl and R 7 , R 9 and R 11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO 2 R 3 , P(O)(OR 4 )(OR 5 ), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R 3 , R 4 and R 5 are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I). |