http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003110522-A1
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
filingDate | 2002-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5474f49b3978a13822cd64311752dab7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15113c4970ef0c7b511d38af08f14d83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f762ba4ccc267c2feafdc1aca53c2346 |
publicationDate | 2003-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2003110522-A1 |
titleOfInvention | Generation of transgenic mouse models for the development of prostate cancer using regulatory regions of the PSP94 gene |
abstract | The utility of the promoter/enhancer region (i.e. regulatory region) of the PSP94 gene in targeting expression of heterologous genes, to the prostate gland was analyzed. Three breeding lines (i.e., line A, line B and line C) of the PSP-TGMAP model described herein were established with constructs containing regulatory regions with or without additional exon/intron sequence of the PSP94 gene. These regulatory regions were operatively linked to the simian virus 40 (SV40) T antigen (Tag, including both the large T and small t antigens). Histopathology evaluation of tumor grade, transgene expression, tumor responsiveness to androgen deprivation and tumor metastatic potential were analyzed and reported herein. This study indicates that regulatory regions (e.g., the promoter/enhancer with exon/intron region) of the PSP94 gene efficiently target the expression of heterologous genes to prostate tissue. Furthermore, the PSP-TGMAP model provides a valuable tool for the analysis of prostate cancer development and for developing new gene therapy vector for the treatment of prostate cancer. Based on this study, mouse PSP94 promoter/enhancer region may be used in the generation of a “shuttle vector” fit for prostate targeting in both mouse CaP model and in human clinical trial. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017325429-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9724430-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017059122-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112425568-A |
priorityDate | 2001-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1101.