http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003109571-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d7463c209152681d030f21b4c09659d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08 |
| filingDate | 2002-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1acdd93d1f986c96dcc4090f1f4adf13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d7eb4d4cb3e93ccdb9ab037461cadbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea86a14d25e2733031360649c01373c7 |
| publicationDate | 2003-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003109571-A1 |
| titleOfInvention | Thromboxane ligands without blood clotting side effects |
| abstract | A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, n n n wherein Y is (CH 2 ) x ; Z is selected from the group consisting of n n n (CR 2 ) x , is an integer of 1 or 2; n is 0 or 1; R 2 is hydrogen or an alkyl radical of from 1 to 4 carbons; A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxa or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein the heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur atoms, or substituted derivatives of said methyl, cycloalkyl or aryl radicals wherein said substituent is selected from the group consisting of halo, nitro, amino, thiol, hydroxy, alkyloxy and alkylcarboxy; and X is selected from the group consisting of nitro, cyano, —COOR, —CH 2 OR 1 , —C(O)N(R 1 ) 2 , —CH 2 N(R 1 ) 2 —CH═N—OH and —CH 2 SR 1 radicals wherein R is a C 1 to C 10 alkyl, phenyl or benzyl and R 1 is R or hydrogen; or a pharmaceutically acceptable salt thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004266776-A1 |
| priorityDate | 1993-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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