http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003108972-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542 |
| filingDate | 2002-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0450c3a8da2745e8a42b883984b5539b |
| publicationDate | 2003-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003108972-A1 |
| titleOfInvention | Tethered receptor-ligand reagent and assay |
| abstract | A tethered reagent and assay is disclosed consisting of protein receptors tethered to ligands. The protein receptors can be antibodies, enzymes, hormone receptors, integral membrane proteins, and other proteins. Ligands can be antigens, enzymatic inhibitors, hormone agonists, drugs, and other protein binding ligands. The protein receptors and ligands will each be labeled with moieties capable of detecting changes in the average distance between the protein receptors and the ligand, using detection methods in which there is a sharp fall-off in signal as a function of distance. As a result, a change in the average distance between the two label moieties, such as that caused by protein-ligand binding and dissociation, produces a change in a detectable signal produced by the reagent. Tethering means may consist of flexible polymers, typically composed of a material that is chemically distinct from either the receptor or the ligand, so that the receptors and ligands may freely associate and dissociate via their specific binding sites, but not totally diffuse away from each other. When bound to solid phase surfaces, such reagents are particularly well suited for proteomic microarrays and flow cells. Such reagents may have utility for immunoassays, enzyme assays, ligand binding assays, sepsis assays, drug screening assays, and drug ADMET assays. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011020833-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005153371-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114054109-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009175845-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691595-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006292559-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9829491-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013176625-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10620195-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017315115-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016075229-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9910040-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010048890-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103913579-A |
| priorityDate | 2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 319.