| abstract |
The invention provides compounds of formula (I) n n n wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, C 1-6 alkoxy, —NR 2 R 3 or —NR 4 SO 2 R 5 ; n is 2 to 6; X is oxygen, sulfur or —CH 2 —; Y is C 1-6 alkyl which may be branched- or straight-chain, and may be independently substituted by one or more halo, C 1-4 alkoxy, hydroxy or C 3-7 cycloalkyl; wherein the linkage —(CH 2 ) n — and the linkage when X is —CH 2 —, may be substituted by C 1-4 alkyl, C 1-4 haloalkyl, hydroxy, C 1-4 alkoxy, C 1-4 haloalkoxy, hydroxyC 1-4 alkyl, C 1-4 alkoxyC 1-4 alkyl, C 1-4 haloalkoxyC 1-4 alkyl, C 3-7 cycloalkyl or C 3-7 cycloalkylC 1-4 alkyl. The compounds of the invention are useful in the treatment of sexual dysfunction, particularly female sexual dysfunction. |