| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate |
1996-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a56e14233cd138b177af22c8d4d70f18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e3316a66aeba9c1cc0e2e64520c2fb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94f82832a91ab280426d1efd3c54fa40 |
| publicationDate |
2003-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003096314-A1 |
| titleOfInvention |
Method and compositions for obtaining mature dendritic cells |
| abstract |
We describe an improved method for generating sizable numbers of mature dendritic cells from nonproliferating progenitors in human blood. The first step or “priming” phase is a culture of T cell depleted mononuclear cells in medium supplemented with GM-CSF and IL-4 to produce immature dendritic cells. The second step or “differentiation” phase requires the exposure to dendritic cell maturation factor such as monocyte conditioned medium. Using this two-step approach, substantial yields are obtained. The dendritic cells derive from this method have all the features of mature cells. They include a stellate cell shape, nonadherence to plastic, and very strong T cell stimulatory activity. The mature dendritic cells produced according to this invention are useful for activating T cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005158336-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8728806-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8093049-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9974854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009246869-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009120891-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9333248-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2470689-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10344262-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018243409-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9993537-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9090673-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10987420-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10596254-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002085993-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009029469-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8563308-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008175830-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7923247-B2 |
| priorityDate |
1996-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |