abstract |
Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: n n n wherein R 1 and R 2 are selected from the group of H, optionally substituted C 1 to C 6 alkyl, alkenyl, alkynyl, or alkynyl groups C 3 to C 8 cycloalkyl, aryl, substituted aryl, or heterocyclic groups, or COR A or NR B COR A ; or R 1 and R 2 are fused to form an optionally substituted ring structure as defined herein; R A and R B are as defined herein; R 3 is H, OH, NH 2 , COR C , or optionally substituted C 1 to C 6 alkyl, C 3 to C 6 alkenyl, or alkynyl groups; R C is as defined herein; Q 1 is S, NR 7 , or CR 8 R 9 ; R 5 is an optionally trisubstituted benzene ring or an optionally substituted five or six membered heterocyclic ring. |