| abstract |
The present invention relates to a compound of formula (I): n n n wherein: n R 3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and n R 4 and R 5 taken together form a ring having from 5 to 10 carbon atoms. n Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A 1 allosteric enhancer. |