| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-124
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-26 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0647 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789 |
| filingDate |
1999-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5014bebc022338dc88f131bd7ec7555e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_106c8b2d17a39e176d4da109ccfe2043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d83fb1755c32c8149307e1babed98a53 |
| publicationDate |
2003-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003044978-A1 |
| titleOfInvention |
Expanded and genetically modified populations of human hematopoietic stem cells |
| abstract |
The present invention provides a method for promoting the survival and/or expansion of hematopoietic stem cells in culture, comprising culturing the cells in a culture including an effective amount of a mpl ligand, (particularly thrombopoietin), a flt3 ligand and interleukin 6 (IL6). Also provided is a method for modifying hematopoietic stem cells comprising contacting a gene delivery vehicle comprising a polynucleotide sequence with a population of hematopoietic stem cells cultured in the presence of an effective amount of thrombopoietin and a flt3 ligand. Additionally methods of restoring hematopoietic capability in a subject are claimed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2233561-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010310535-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010310536-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004098508-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004046312-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005276793-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7927785-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2228434-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2228435-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010310537-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9115341-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2228435-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2233561-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2228434-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273503-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7790458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006005360-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004046312-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017075389-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004098508-A2 |
| priorityDate |
1998-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |