| abstract |
The composition for the cell-specific transfer of an active compound in specific target cells can be used as a diagnostic or therapeutic agent or for gene therapy. The composition includes virus-like particles, which are each composed of a number of viral protein molecules derived from JC virus, a cationic polymer, for example a polyamine, a polyimine or an amino acid polymer, especially polyethylenimine, as an anchor molecule for a cell-specific ligand, and preferably a ligand bound to the cationic polymer as a binding partner for a cell-specific receptor. The viral protein is advantageously encoded with a nucleic acid having nucleotide sequence as shown by SEQ. ID NO. 1. |