| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-40 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 |
| filingDate |
2002-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d1da73527902da2c964bf1b144f345b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_412f2e37e3fbb01016dc9d198e30594c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09277533912e4e3e6af235d13896831a |
| publicationDate |
2003-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003044356-A1 |
| titleOfInvention |
Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one) |
| abstract |
The present invention relates to antiemetic nasal spray composition comprising n (1) 2-8 parts by weight of ondansetron hydrochloride as an antiemetic drug; and n (2) 100 parts by weight of base material for nasal administration consisting of (i) 70-85% by weight of water, (ii) 5-15% by weight of polyethylene glycol, (iii) 0.005-0.02% by weight of benzalkonium chloride and (iv) 7-20% by weight of one solubilizer selected from sulfobutyl ether β-cyclodextrin sodium salt, dimethyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin, the total amount of the above base material being 100% by weight. n The antiemetic composition according to the present invention is feasible for nasal administration, and rapidly exerts its antiemetic effect within 30 minutes upon administering it to a human being. In addition, since nasal bioavailability of ondansetron hydrochloride as an active ingredient is highly improved, the required effect can be attained even by administering relatively small amount of the active ingredient. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9050325-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006045850-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014303221-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016206610-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020268705-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011288115-A1 |
| priorityDate |
2001-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |