| abstract |
A method of producing analgesia in a mammal is provided by intrathecal administration to the mammal of a pharmaceutically effective dose of the opioid receptor-like receptor 1 (ORL-1) agonist (1S,3aS)8-(2,3,3a,4,5,6-hexahydro-IH-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one. Administration may be carried out through use of an implantable apparatus. |