| abstract |
A heterocyclic compound of the formula [I] n n n wherein R 1 is hydrogen atom or lower alkyl, R 2 is hydrogen atom, alkyl optionally having a substituent and the like, R 3 is hydrogen atom, lower alkyl and the like, A is a single bond or >N—R 5 wherein R 5 is hydrogen atom or lower alkyl, B is lower alkylene, and Y is aryl optionally having a substituent and the like, and a pharmaceutically acceptable salt thereof show a hypoglycemic action, a blood hypolipidemic action, an insulin resistance-improving action and a PPAR activating action, and are useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complication, a glucose tolerance improver, an anti-atherosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated disease and an agent for the prophylaxis or treatment of syndrome X. |