http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003027251-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B50-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2001-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05761034b15862c2639cdb6776dcd5dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35d17f8293970f73a2c376e4db9740bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9e01708afaddaf5f7c6ea57fbe1c034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cec4075c413da88d03ad2dbd8c47b868 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdbaaf3e408630a81086b54f8b53c16a |
| publicationDate | 2003-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003027251-A1 |
| titleOfInvention | Assays for inhibitors of FtsH |
| abstract | This invention provides a bacterial system and assay for detecting and quantifying activity of bacterial growth regulator, FtsH. The bacteria include three expression cassettes. An FtsH expression cassette comprises a first promoter operatively linked to a nucleotide sequence encoding FtsH. A transcriptional regulator expression cassette comprises a second promoter operatively linked to a nucleotide sequence encoding a transcriptional regulator which regulates the activity of a third promoter, wherein the transcriptional regulator is a substrate of FtsH. A reporter expression cassette comprises the third promoter operatively linked to a reporter gene. The activity of FtsH can be read out as a positive expression of the reporter gene. The invention also provides an assay for compounds that modulate the expression of FtsH. The assay involves contacting the recombinant bacterial cell with the agent, and determining whether the agent modulates the expression of the reporter gene. |
| priorityDate | 1999-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 630.