| abstract |
The present invention relates to bicyclic compounds wherein one of the cyclic moieties is a 16-membered macrocycle and to methods for making and using these compounds. The present invention provides compounds of the formula n n n wherein: n R 1 , R 2 , and R 3 are each independently hydrogen, methyl or ethyl; n R 4 is hydrogen, hydroxyl, fluoro, oxo, oximino, or NRR′ where R and R′ are independently hydrogen, C 1 -C 10 aliphatic, aryl or alkylaryl; n R 5 is hydrogen, oxo, or C 1 -C 10 aliphatic; n R 6 is hydrogen, hydroxyl, oxo, C 1 -C 10 aliphatic, C 1 -C 10 alkylester, or halide, or optionally R 5 and R 6 together form a carbon-carbon bond; n R 7 is hydrogen, methyl, ethyl, methoxy, or OH; n X is fused substituted or unsubstituted heterocyclo; n Y is substituted or unsubstituted heterocyclo; n R 9 is aryl or —CH═C(Me)-Aryl; and, n W is O or NR 8 where R 8 is hydrogen, C 1 -C 10 aliphatic, aryl or alkylaryl. |