abstract |
The present invention is directed to complexes of the protein p27(Kip1) with proteins identified as interacting with p27(Kip1) by a yeast mating test. Specifically, the present invention is directed to complexes with p27(Kip1) and FKBP-12. The present invention is also directed to complexes of a derivative, fragment or analog of p27(Kip1) and a derivative, fragment or analog of FKBP-12. Methods of screening the complexes for efficacy in treating and/or preventing certain diseases and disorders, particularly hyperproliferative disorders, including cancer, neurodegenerative disease, autoimmune disease, are also provided. |