| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d0446a5bd77c7da68216fc2e3f05d48 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
2002-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_114901f877e4d1def82e151f20cff276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3118bdd3b1a8fbaf3462c2617692be91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff456b7f4a546937e324d864f550a77e |
| publicationDate |
2003-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003022244-A1 |
| titleOfInvention |
Single chain antibody against mutant P53 |
| abstract |
More than 90% of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and methods of treatment using the pharmaceutical compositions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113528467-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8853382-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012019058-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014093417-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11117976-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016154246-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007056352-A2 |
| priorityDate |
2000-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |