| abstract |
The invention relates to the preparation of novel polyamines, such as derivatives of 1,3-bis-[(2′-aminoethyl)-amino]propane (2,3,2-tetramine) and 1,4,8,11-tetraazacyclotetradecane (cyclam), which can be used to treat mitochondrial and degenerative diseases. n Accordingly, in one aspect the invention is directed to compounds of the formula: n n n wherein n R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and are hydrogen, alkyl, aryl, cycloalkyl, amino acid, glutathione, urate, ascorbate, estrogen, dehydroepiandrosterone, redox stabilizing substituents, a quinone, glutamate, succinate, —(CH 2 ) n [XCH 2 ) n ]NH 2 — wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon, or heterocycle wherein R 1 to R 6 taken together are —(CH 2 XCH 2 ) n — wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon. n M, n, and p may be the same or different and are bridging groups of variable length from 3-12 carbons. n X 1 and X 2 may be the same or different and are nitrogen, sulfur, phosporous or carbon. |